State Road 58 will be closing for up to three months in Jackson County near Spraytown starting next Monday.
INDOT says that Milestone Contractors will be replacing a bridge on the highway over Branch Runt Run, about two miles east of State Road 258.
The detour route follows State Road 135, U.S. 50 and I-65.
The work schedule is dependent on the weather.
INDOT asks you to slow down, to drive without distractions and to alert to worker safety in all construction zones.